Inhibition of acetylcholinesterase activity and Fe2+-induced lipid peroxidation in rat brain in vitro by some citrus fruit juices.
Identifieur interne : 001274 ( Main/Exploration ); précédent : 001273; suivant : 001275Inhibition of acetylcholinesterase activity and Fe2+-induced lipid peroxidation in rat brain in vitro by some citrus fruit juices.
Auteurs : Ayokunle O. Ademosun [Nigeria] ; Ganiyu ObohSource :
- Journal of medicinal food [ 1557-7600 ] ; 2012.
English descriptors
- KwdEn :
- Acetylcholinesterase (metabolism), Alzheimer Disease (drug therapy), Alzheimer Disease (metabolism), Animals, Antioxidants (pharmacology), Beverages, Biphenyl Compounds (metabolism), Brain (drug effects), Brain (metabolism), Cholinesterase Inhibitors (pharmacology), Citrus, Dose-Response Relationship, Drug, Fruit (chemistry), Iron (adverse effects), Lipid Peroxidation (drug effects), Malondialdehyde (metabolism), Oxidative Stress (drug effects), Phenols (analysis), Phenols (pharmacology), Picrates (metabolism), Plant Preparations (chemistry), Plant Preparations (pharmacology), Rats.
- MESH :
- chemical , adverse effects : Iron.
- chemical , analysis : Phenols.
- chemical , chemistry : Plant Preparations.
- chemical , metabolism : Acetylcholinesterase, Biphenyl Compounds, Malondialdehyde, Picrates.
- chemistry : Fruit.
- drug effects : Brain, Lipid Peroxidation, Oxidative Stress.
- drug therapy : Alzheimer Disease.
- metabolism : Alzheimer Disease, Brain.
- chemical , pharmacology : Antioxidants, Cholinesterase Inhibitors, Phenols, Plant Preparations.
- Animals, Beverages, Citrus, Dose-Response Relationship, Drug, Rats.
Abstract
This study sought to characterize the effects of some citrus fruit juices (shaddock [Citrus maxima], grapefruit [Citrus paradisii], lemon [Citrus limoni], orange [Citrus sinensis], and tangerine [Citrus reticulata]) on acetylcholinesterase activity in vitro. The total phenolic content, radical scavenging abilities, and inhibition of Fe(2+)-induced malondialdehyde (MDA) production in rats brain homogenate in vitro were also assessed. Orange had significantly (P<.05) higher phenolic content than the other juices. The juices scavenged 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals in a dose-dependent manner with orange having the highest scavenging ability. Furthermore, the juices inhibited Fe(2+)-induced MDA production in rat brain homogenate in a dose-dependent manner with shaddock having the highest inhibitory ability. Acetylcholinesterase activity was also inhibited in vitro by the juices in a dose-dependent manner. The inhibition of acetylcholinesterase activity and antioxidant properties of the citrus juices could make them a good dietary means for the management of Alzheimer's disease.
DOI: 10.1089/jmf.2011.0226
PubMed: 22400910
Affiliations:
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Le document en format XML
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Ademosun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, Federal University of Technology, Akure, Ondo-State</wicri:regionArea><wicri:noRegion>Ondo-State</wicri:noRegion></affiliation></author><author><name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22400910</idno><idno type="pmid">22400910</idno><idno type="doi">10.1089/jmf.2011.0226</idno><idno type="wicri:Area/PubMed/Corpus">000618</idno><idno type="wicri:Area/PubMed/Curation">000618</idno><idno type="wicri:Area/PubMed/Checkpoint">000618</idno><idno type="wicri:Area/Ncbi/Merge">000F32</idno><idno type="wicri:Area/Ncbi/Curation">000F32</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F32</idno><idno type="wicri:Area/Main/Merge">001288</idno><idno type="wicri:Area/Main/Curation">001274</idno><idno type="wicri:Area/Main/Exploration">001274</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibition of acetylcholinesterase activity and Fe2+-induced lipid peroxidation in rat brain in vitro by some citrus fruit juices.</title><author><name sortKey="Ademosun, Ayokunle O" sort="Ademosun, Ayokunle O" uniqKey="Ademosun A" first="Ayokunle O" last="Ademosun">Ayokunle O. Ademosun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Biochemistry, Federal University of Technology, Akure, Ondo-State</wicri:regionArea><wicri:noRegion>Ondo-State</wicri:noRegion></affiliation></author><author><name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name></author></analytic><series><title level="j">Journal of medicinal food</title><idno type="eISSN">1557-7600</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholinesterase (metabolism)</term><term>Alzheimer Disease (drug therapy)</term><term>Alzheimer Disease (metabolism)</term><term>Animals</term><term>Antioxidants (pharmacology)</term><term>Beverages</term><term>Biphenyl Compounds (metabolism)</term><term>Brain (drug effects)</term><term>Brain (metabolism)</term><term>Cholinesterase Inhibitors (pharmacology)</term><term>Citrus</term><term>Dose-Response Relationship, Drug</term><term>Fruit (chemistry)</term><term>Iron (adverse effects)</term><term>Lipid Peroxidation (drug effects)</term><term>Malondialdehyde (metabolism)</term><term>Oxidative Stress (drug effects)</term><term>Phenols (analysis)</term><term>Phenols (pharmacology)</term><term>Picrates (metabolism)</term><term>Plant Preparations (chemistry)</term><term>Plant Preparations (pharmacology)</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Iron</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Phenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Preparations</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholinesterase</term><term>Biphenyl Compounds</term><term>Malondialdehyde</term><term>Picrates</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fruit</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Lipid Peroxidation</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term><term>Cholinesterase Inhibitors</term><term>Phenols</term><term>Plant Preparations</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Beverages</term><term>Citrus</term><term>Dose-Response Relationship, Drug</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study sought to characterize the effects of some citrus fruit juices (shaddock [Citrus maxima], grapefruit [Citrus paradisii], lemon [Citrus limoni], orange [Citrus sinensis], and tangerine [Citrus reticulata]) on acetylcholinesterase activity in vitro. The total phenolic content, radical scavenging abilities, and inhibition of Fe(2+)-induced malondialdehyde (MDA) production in rats brain homogenate in vitro were also assessed. Orange had significantly (P<.05) higher phenolic content than the other juices. The juices scavenged 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals in a dose-dependent manner with orange having the highest scavenging ability. Furthermore, the juices inhibited Fe(2+)-induced MDA production in rat brain homogenate in a dose-dependent manner with shaddock having the highest inhibitory ability. Acetylcholinesterase activity was also inhibited in vitro by the juices in a dose-dependent manner. The inhibition of acetylcholinesterase activity and antioxidant properties of the citrus juices could make them a good dietary means for the management of Alzheimer's disease.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country></list><tree><noCountry><name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name></noCountry><country name="Nigeria"><noRegion><name sortKey="Ademosun, Ayokunle O" sort="Ademosun, Ayokunle O" uniqKey="Ademosun A" first="Ayokunle O" last="Ademosun">Ayokunle O. Ademosun</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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